Target HER2 in GI

Artistic gastrointestinal tract coiled around HER2.0

HER2 is central to tumor growth and crucial to target

The HER2 pathway plays a critical role in tumor growth, and current targeted options are limited1,2

Cell proliferation icon

HER2 activates pathways that drive cell survival, proliferation, and differentiation. HER2 overexpression hyperactivates these pathways to fuel tumor growth3,4

Block tumor growth icon

Blocking HER2 is critical to slowing tumor growth and improving patient outcomes4,5

  • HER2-positivity may be associated with worse outcomes in biliary tract cancer when targeted treatment is not used5
Single-site binding mAb icon

Current HER2-targeted approaches, including single-site binding mAbs and mAb combinations, may offer limited activity2,6

PATIENTS WITH HER2-DRIVEN GI CANCERS DESERVE BETTER OUTCOMES

 

GI=gastrointestinal; HER2=human epidermal growth factor receptor 2; mAb=monoclonal antibody.

References


1. Bonomi M, Spada D, Baiocchi GL, Celotti A, Brighenti M, Grizzi G. Targeting HER2 in gastroesophageal adenocarcinoma: molecular features and updates in clinical practice. Int J Mol Sci. 2024;25(7):3876. doi:10.3390/ijms25073876 2. Zhao D, Klempner SJ, Chao J. Progress and challenges in HER2-positive gastroesophageal adenocarcinoma. J Hematol Oncol. 2019;12(1):50. doi:10.1186/s13045-019-0737-2 3. Sun Y, Puspanathan P, Lim T, Lin D. Advances and challenges in gastric cancer testing: the role of biomarkers. Cancer Biol Med. 2025;22(3):212-230. doi:10.20892/j.issn.2095-3941.2024.0386 4. Li W, Zhang X, Du Y, et al. HER2-targeted advanced metastatic gastric/gastroesophageal junction adenocarcinoma: treatment landscape and future perspectives. Biomark Res. 2022;10:71. doi:10.1186/s40364-022-00416-x 5. Lee CH, Seo DH, Fox D, et al. Impact of HER2-positivity on prognosis and targeted therapeutic outcomes in advanced biliary tract cancer. Presented at: ASCO Gastrointestinal Cancers Symposium; January 23-25, 2025; California, USA. 6. Fine J, Meksiriporn B, Tan J, Spangler JB. Mechanism-driven design of multispecific antibodies for targeted disease treatment. Annu Rev Chem Biomol Eng. doi:10.1146/annurev-chembioeng-100522-102155